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Efferent Neurons Can Usually Be Classified Assignment

Cells that make up the Nervous System

The nervous system can be divided into two sections – the central nervous system (CNS) and the peripheral nervous system (PNS). Our nervous system performs three major functions in the body:

  1. It receives information from sites on cells where particular chemicals can bind to and so change the activity of the cell. These sites are called receptors.
  2. It processes this information and determines the appropriate response by inergrating all the incoming signals from the receptors.
  3. It signals other cells and body organs to perform the appropriate response.

There are two main type of cells that make up the nervous system – neurons and glial cells.

Neurons

An single nerve cell is called a neuron. There are about a trillion neurons in the human nervous system!

These important cells enable communication within the nervous system. To carry out this function, neurons possess certain crucial properties:

  • All neurons are very excitable, meaning that they are able to respond to environmental stimuli very well.
  • Neurons conduct electricity very well. This allows them to respond to stimuli by producing electrical signals that travel very quickly to cells that may be at a distance.
  • Neurons are secretory cells. This means that when an electrical signal is transmitted to the end of the neuron, the cell secretes a particular chemical messenger called a neurotransmitter. The neurotransmitter then stimulates other cells around the neuron.

Neurons are divided into three basic sections:

  • Cell body. As the name suggests, this is the main body part of the cell. The key organs needed for cell survival are located in the cell body.
  • Dendrites. These are similar to antenna projecting outwards from the cell body. They increase the surface area available to receive signals from other neurons. A neuron can sometimes have up to 400,000 dendrites!
  • Axon. The axon is also known as the nerve fibre. It is an enlongated tubular structure that extends from the cell body and ends at other cells. It conducts electrical signals called action potentials away from the neuron. Axons can vary in length, ranging from less than a millimetre to longer than a metre. For example, the axon of the neuron that innervates your big toe must travel the distance from the origin of its cell body which located in the spinal cord in your lower back, all the way down your leg to your toe.
    • The axon hillock is the first portion of the axon, and the region of the cell body from which the axon leaves. The axon hillock is also known as the trigger zone, because this is where action potentials are started.
    • The axon terminal is the end of the axon where action potentials are conducted down to. It is here that neurotransmitters are released.

There are three types of neurons in the nervous system – afferent, efferent and interneurons.

Afferent Neurons

Afferent neurons carry signals towards the CNS – afferent means “towards”. They provide information about the external environment and the regulatory functions being carried out by the nervous system.

An afferent neuron has a receptor at its ending that generates action potentials in response to a particular stimulus. These action potentials are transmitted along the length of the axon towards the spinal cord (which is part of the CNS).

Efferent Neurons

Efferent neurons are mainly located in the peripheral nervous system, but their cell bodies orginate in the CNS. Many incoming signals from the CNS converge onto the efferent neurons, which then affect the outgoing signals to various organs in the body. These organs then carry out the appropriate response.

Interneurons

Interneurons are located entirely within the CNS. They make up about 99% of all neurons and have two main functions:

  1. They are located between afferent and efferent neurons, and therefore work to integrate all the information and response from these neurons together. For example, afferent neurons receive information when you touch a hot stove with your hand. Upon receiving this signal, the corresponding interneurons send signals to efferent neurons which then transmit messengers to the hand and arm muscles to tell them to pull away from the hot object.
  2. The connections between the interneurons themselves are responsible for various abstract phenomenon of the mind, including emotion and creativity.

Glial Cells

As previously mentioned, in addition to neurons, glial cells are the other major cell type that make up the nervous system. Glial cells are also called neuroglia. Although they are not as well known as neurons, they make up about 90% of cells within the CNS. However, they only occupy about half of the space in the brain because they do not have extensive branching like neurons. Unlike neurons, glial cells do not conduct nerve electrical signals. They instead serve to protect and nourish the neurons. Neurons depend on glial cells to grow, nourish themselves, and establish effective synapses. The glial cells of the CNS therefore support the neurons both physically and chemically via processes needed for cell survival. In addition, they maintain and regulate the composition of the fluid surrounding the neurons in the nervous system. This is very important because this environment is highly specialised, and very narrow limits are required for optimal neuronal function. Glial cells also actively participate in enhancing synaptic function.

There are four major types of glial cells in the CNS – astrocytes, oligodendrocytes, microglia and ependymal cells. There are also two types of glial cells in the PNS – Schwann cells and satellite cells.

Astrocytes

“Astro” means “star” and “cyte” means cell. Astrocytes are so named because they have a star-like shape. They are the most abundant glial cells and have the following crucial functions:

  • They act as a “glue” to hold neurons together in their proper positions
  • They serve as scaffolding to guide neurons to their proper destination during brain development in the foetus
  • They cause the small blood vessels in the brain to change and establish the blood-brain barrier
  • They help in repairing brain injuries and in forming neural scar tissue
  • They play a role in neurotransmitter activity by bringing the actions of some chemical messengers to a halt by taking up the chemicals. They also break down these taken-up chemicals and transform them into raw materials that are used to make more of these neurotransmitters
  • They take up excess potassium ions from brain fluid to help stabilise the ratio between sodium and potassium ions
  • They enhance the formation and functioning of synapses by keeping in communication with each other and with neurons.

Oligodendrocytes

Oligodendrocytes form sheaths around the axons of the CNS that serve as insulation. These sheaths are made of myelin, which is a white material that enables the conduction of electrical impulses.

Microglia

Microglia act as the immune defence cells of the CNS. They are made of the same tissues as monocytes, which are a type of white blood cell that leaves the blood and sets up a front-line defence against invading organisms throughout the body.

Ependymal Cells

Ependymal cells line the internal cavities of the CNS. The ependymal cells that line the cavities of the brain also contribute to the formation of cerebrospinal fluid (CSF). These cells have tail-like projections called cilia. The beating of this cilia assists the flow of CSF throughout the brain cavities. Ependymal cells also act as stem cells in the brain, and have the potential to form other glial cells and new neurons which are only produced in specific site of the brain. Neurons in most of the brain are considered to be irreplaceable.

Schwann Cells

Schwann cells are wound repeatedly around nerve fibres in the peripheral nervous system, producing a myelin sheath similar to the membrane produced by oligodendrocytes in the CNS. They also play a role in the regeneration of damaged fibres.

Satellite Cells

Satellite cells surround the cell bodies of neurons in the ganglia of the PNS. Their function has not been properly defined yet.

Synapses

A synapse typically involves a junction between an axon terminal of one neuron, known as the presynaptic neuron, and the dendrites or cell body of a second neuron, known as the postsynaptic neuron. Less frequently, axon-to-axon or dendrite-to-dendrite connections occur. Some neurons within the CNS have been estimated to receive as many as 100 000 synaptic inputs!

What does a synapse look like?

The axon terminal of the presynaptic neuron conducts electrical signals called action potentials towards the synapse. The end of the axon terminal has a slight swelling known as the synaptic knob. This is where chemical messengers called neurotransmitters are made and strored. The synaptic knob of the presynaptic neuron is located near the postsynaptic neuron. The space between the two neurons is called the synaptic cleft, and is too wide to allow current to pass directly from one cell to another, preventing the transference of action potentials between neurons.

Synapses only operate in one direction. Presynaptic neurons influence the cell membrane voltage (known as the cell membrane potential) of postsynaptic neurons, but postsynaptic neurons cannot directly affect presynaptic neuron membrane potentials.

What happens at a synapse?

  1. A electrical signal (an action potential) is initiated and transmitted to the axon terminal of the presynaptic neuron. This stimulates voltage-regulated calcium ion channels in the synaptic knob to open.
  2. The concentration of calcium ions becomes much higher outside the neuron compared to inside, so calcium ions flow into the synaptic knob through the open calcium channels.
  3. The increased calcium ion concentration inside the neuron causes the release of neurotransmitter from the synaptic cleft.
  4. The neurotransmitter moves across the synaptic cleft, and binds to receptors on the postsynaptic neuron.
  5. Binding of the neurotransmitter to its receptor causes the opening of chemically-regulated ion channels on the postsynaptic neuron, allowing different ions to enter or leave the postsynaptic neuron.

Excitatory synapses

An excitatory synapse is one where the postsynaptic neuron becomes more excitable as a result of synaptic events. At such a synapse, a neurotransmitter binds to its receptor on the postsynaptic neuron. This leads to a few potassium ions moving out of the cell, and many sodium ions moving into the cell. Both potassium and sodium ions carry one positive charge, so the overall effect is that the inside of the cell membrane becomes slightly more positive, making it easier for action potentials to be elicited compared to when the cell is at rest. This change in membrane voltage at an excitatory synapse is called an excitatory postsynaptic potential (EPSP).

Inhibitory synapses

An inhibitory synapse is one where the postsynaptic neuron becomes less excitable as a result of synaptic events. At such a synapse, a neurotransmitter binds to its receptor on the postsynaptic neuron. This leads to potassium ions leaving the cell, and chloride ions entering the cell. Potassium ions carry a positive charge while chloride ions carry a negative charge, so the overall effect is that the inside of the cell membrane becomes slightly more negative, making it more difficult for action potentials to be elicited compared to when the cell is at rest. This change in membrane voltage at an inhibitory synapse is called an inhibitory postsynaptic potential (IPSP).

What is the Central Nervous System (CNS)?

The central nervous system is one part of the body’s overall nervous system. It is made up of the brain and the spinal cord, which are located within and protected by the skull and the vertebral column respectively. The other part of the nervous system is called the peripheral nervous system (PNS). This is made up of all the parts of the nervous system that are not part of the CNS.

Interactions between the central and peripheral nervous systems

The peripheral nervous system (PNS) is made up of nerves and ganglia (clusters of nerve cells). The PNS and CNS work together to send information between the brain and the rest of the body. Nerves emerge from the CNS through the skull and vertebral column, using the PNS to carry information to the rest of the body.

The PNS is made up of two divisions – sensory and motor. The sensory division carries signals from all over the body back to the CNS to be decoded, while the motor division carries signals from the CNS to cells all over the body to carry out the body’s responses to this information.

Parts of the CNS

There are six main parts of the CNS. These are:

  1. Spinal cord
  2. Medulla
  3. Pons and cerebellum (which along with the medulla, form the brain stem)
  4. Midbrain
  5. Diencephalon
  6. Cerebral hemisphere

The last 5 components of the CNS mentioned above are all part of the brain.

Grey matter and white matter

Within these six divisions, there are other sub-regions. These are divided according to what kind of structures they are primarily made up of. One region is called grey matter. Grey matter is mainly made up of cell bodies and dendrites. It is called grey matter because it has a grey appearance in fresh material. The other region is called white matter, and has a white appearance in fresh tissue. White matter is mainly composed of axons, which give it its white colour because of a membrane around the axons known as a myelin sheath.

Spinal cord

The spinal cord has in important role in controlling the muscles of the limbs and the trunk, as well as the functions of internal body organs. It also processes information from these structures, and sends information to and from the brain.

The spinal cord is divided into many segments. It also contains a pair of roots called the dorsal and ventral roots. These roots become intermingled with the spinal nerves, and contain sensory and motor axons which are part of the PNS. The axons and spinal nerves work together to transfer information between the muscles and organs of the body, and the spinal cord.

Brain stem

The brain stem is made up of the medulla, pons and cerebellum. It has the following functions:

  1. Receive incoming information from structures in the skull.
  2. Transmit information between the spinal cord and higher brain regions.
  3. Put together the actions of the different parts of the brain stem to regulate levels of stimulation.

Medulla: The medulla is located just above the spinal cord. It contains structures known as pyramids that carry signals from the cerebrum to the spinal cord. This stimulates the skeletal muscles in the body, which are generally the muscles used to create movement. The medulla also receives information from the spinal cord and other parts of the brain, and transfers it to the cerebellum.

Parts of the medulla also receive information from the taste buds, the pharynx, as well as the chest and abdominal cavities. The cell structures that receive this information have several functions, including:

  1. Controlling heart rate and how hard the heart pumps
  2. Controlling blood pressure
  3. Controlling how fast and how hard breathing is

The medulla also plays important roles in speaking, swallowing, coughing/sneezing, vomiting, sweating, salivation, and tongue and head movements.

Pons and cerebellum: The pons is a bulge at the front of the brainstem, while the cerebellum is located underneath the cerebrum. The pons transfers information from the cerebrum to the cerebellum, and is also involved in sleeping, hearing, balance, facial sensation/expression, breathing, and swallowing. The cerebellum has roles in muscle coordination, emotion, and cognitive processes such as judgement.

Midbrain

The midbrain connects the hindbrain and the forebrain to each other. It is divided into different regions:

  • Cerebral peduncles
  • Tegmentum
  • Substantia nigra
  • Central grey matter
  • Tectum
  • Medial lemniscus

Diencephalon

The diencephalon is made up of two components called the thalamus and the hypothalamus.

Thalamus: The thalamus has an important role in transferring information to the cerebral hemispheres. In turn, it receives information from areas in the cerebrum. Signals from all over the body are also sent to the thalamus, which directs this information to the cerebrum to be processed.

The thalamus is closely interconnected with the system responsible for emotion and memory – the limbic system. Eye movements, taste, smell, hearing and balance are also linked to the thalamus.

Hypothalamus: The hypothalamus is the major control centre of the autonomic nervous system, therefore playing important roles in ensuring all the systems in the body function smoothly. It is also involved in the release of hormones from the pituitary. The hypothalamus is involved in many body functions including the following:

  1. Hormone secretion
  2. Autonomic effects (acting as a control system for the body)
  3. Regulating body temperature
  4. Detecting food and water intake (making you feel hungry or thirsty)
  5. Sleep and waking
  6. Memory
  7. Emotion and behaviour

Cerebral hemispheres

The cerebral hemispheres are made up of four major parts:

  1. Cerebral cortex
  2. Basal ganglia
  3. Hippocampus
  4. Amydala

Cerebral cortex: The cerebral cortex is located on the surface of the cerebral hemispheres. It is highly convoluted and folded. This allows a large surface area to fit inside the confined space of the skull. The cerebral cortex is divided into four lobes called the frontal lobe (front lobe), the parietal lobe (between front and back lobes), the occipital lobe (back lobe) and the temporal lobe (side lobes).

Basal ganglia:Basal ganglia are collections of cells that are located deep inside the brain and have important roles in many higher brain functions. One function in which they play an important part is the control of movement.

In Parkinson’s disease, the basal ganglia are damaged. Patients with Parkinson’s disease experience tremors and a slowing of movement as a result. Basal ganglia also influence other aspects of behaviours such as cognition and emotion.

Hippocampus: The hippocampus has an important role in the formation of memories. It is also part of the limbic system, which influences thought and mood.

Amydala: The amydala coordinates the release of hormones and the actions of the autonomic nervous system. It is also part of the limbic system, and has a role in emotion.

Meningeal layers

The meningeal layers are sometimes referred to as meninges. They are three separate layers that enclose the brain and spinal cord. Their roles are mainly to protect the brain and to circulate blood to and from the brain. The three layers are:

  1. Dura mater
  2. Arachnoid mater
  3. Pia mater

Dura mater: Dura mater is the outermost of the meningeal layers. It is the thickest membrane. The dura around the cerebral hemispheres and the brainstem is actually made up of two layers. The outer of these layers is attached to the inside of the skull.

Arachnoid mater: The arachnoid mater is the middle meningeal layer. It lies next to the dura mater, but is not tightly bound to it. The space existing between the two layers is known as the subdural space. Breaking of a blood vessel in the dura mater can cause bleeding and a formation of a blood clot in this subdural space, resulting in a subdural haematoma. This is dangerous because the blood clot can push the arachnoid and dura layers apart, compressing the brain tissues.

Pia mater: The pia mater is the innermost meningeal layer, adhering to the brain and the spinal cord. It is a delicate layer and is separated from the arachnoid mater by a space known as the subarachnoid space. The space is filled with cerebrospinal fluid (CSF) and contains the veins and arteries overlaying the surface of the CNS.

Cerebrospinal fluid (CSF)

Cerebrospinal fluid (CSF) bathes the inside of the brain through a network of cavities within the CNS known as the ventricular system. CSF has the following functions:

  1. Buoyancy. The brain neither sinks nor floats in CSF, but instead remains suspended in it because the two components have very similar densities. This allows the brain to grow to an attainable size without being impaired by its own weight. If the brain were allowed to rest on the floor of the skull, the pressure from its own weight would kill the nervous tissue.
  2. Protection. CSF protects the brain from striking the inside of the skull when the head is jolted. However, there is a limit to this protection as a severe jolt can still result in the brain damaging itself by striking or shearing against the floor of the skull.
  3. Chemical stability. CSF ends up being absorbed into the bloodstream. This provides a way of clearing wastes from the CNS, and also allows it to maintain its optimal chemical environment. Slight changes in its composition can cause malfunctions of the nervous system. For example, if the CSF is too basic (not acidic enough), it can lead to dizziness and fainting.

How does the CNS develop?

A human embryo consists of three major cell layers known as the ectoderm, mesoderm and endoderm. The CNS develops from a specialised region of the ectoderm called the neural plate. The process through which the neural plate starts to form the nervous system is called neural induction.

The neural plate lies along the midline of the embryo. A midline indentation forms and deepens along the neural plate to form a groove known as the neural groove. This groove then closes to form a hollow tube known as the neural tube. All major components of the CNS are then present including the spinal cord and brain stem.

What happens to the CNS as we age?

The functioning of the nervous system changes from childhood to old age, reaching its peak development at around the age of 30. Different aspects of brain function tend to be affected at different ages. For example, vocabulary and the use of words start to decline at around age 70, while the ability to process information can be maintained until age 80 if no neurological disorders are present.

As aging occurs, the overall number of nerve cells starts to decline. A brain generally weighs 56% less at the age of 75 than at the age of 30 due to this decrease in brain cells. Overall brain function is also slowed due to several factors. These include less efficient synapses and the slowing down of the transmission of electrical signals between neurons.

Engaging in mental and physical activity (ie. exercise) can help to slow the decline in brain functioning, especially in the area of memory. Conversely, consuming 2 or more standard alcoholic drinks per day can speed up the decline in brain activity.

However, not all functions of the CNS are affected in the same way by old age. Although skills such as motor co-ordination, intellectual function and short-term memory decline, language skills and long-term memory can be retained, in the absence of any neurological pathology. Elderly people often remember things in the distant past better than recent events.

How do maternal factors affect brain development during pregnancy?

Alcohol

Foetal alcohol syndrome (FAS) and other congenital abnormalities are freqently linked to alcohol exposure. FAS is one of the most frequent causes of non-genetic mental retardation. Features of FAS include:

  • Facial abnormalities, including small eye openings, flattened cheekbones, depressed nasal bridge, and an underdeveloped groove between the nose and upper lip
  • Growth retardation, resulting in low birth weight
  • Brain dysfunctions ranging from moderate learning difficulties to severe mental retardation
  • Defects in vision and hearing

There is no “safe” amount of alcohol that a pregnant woman can consume without any risk for her foetus. It is strongly recommended that pregnant women do not consume any alcohol at all.

Drugs

Heroin and methadone: Heroin and its substitute, methadone, are often taken together with other toxins such as cocaine, alcohol or tobacco. The exact nature of these drugs on the developing brain is not well studied. However, laboratory studies suggest that they can greatly influence brain development, causing changes in brain cells under laboratory conditions.

Cocaine: Like most other toxins, cocaine is associated with an increased risk of prematurity and intra-uterine growth retardation. Cocaine exposure during development has been linked to microcephaly, malformations of the brain, and several other brain defects. After birth, effects of cocaine can include sleep disturbances, difficulties in feeding, and epileptic fits. These symptoms generally disappear within the first year of life.

However, some chidren who were exposed to cocaine as a foetus develop long-term neurological difficulties. Their IQ is generally within the normal range, but they may often exhibit difficulties concentrating, becoming distracted easily, and behave aggressively or impulsively. They are also at increased risk of developing anxiety or depressive disorders.

Caffeine: Caffeine is broken down more quickly during pregnancy, and some animal studies suggest that caffeine is concentrated in the developing brain. Caffeine by itself, when taken in low to moderate amounts, does not appear to greatly increase the risk of foetal malformations.

Smoking: Maternal smoking is major risk factor for sudden infant death symdrome (SIDS). It is also linked to increased risk of growth retardation and conduct disorder (a psychiatric disorder). Two susbstances found in cigarette smoke, carbon monoxide and nicotine, affect the foetal brain by acting directly on it, or by causing a lack of oxygen supply.

Maternal diabetes

Maternal diabetes can be type I, type II, or gestational diabetes. All three increase the risk of foetal brain malformation. However, these can be prevented by following a special program designed for pregnant diabetic women to keep their condition under control. Patients’ doctors will normally advise diabetic pregnant women on these programs.

References

  1. Gressens P, Mesples B, Sahir N, Marret S, Sola A. Environmental factors and disturbances of brain development. Semin Neonatol 2001; 6:185-194.
  2. Martin JH. Neuroanatomy – Text and atlas. Appletone & Lange: Connecticut; 1989.
  3. Saladin KS. Anatomy and physiology – the unity of form and function. 3rd ed. New York: McGraw-Hill; 2004.
  4. Sherwood LS. Human physiology – from cells to systems. 5th ed. Belmont: Brooks/Cole – Thomson Learning; 2004.
  5. Goldman SA. Effects of Aging. Merck 2007 [cited 2008 20th April]; Available from: http://www.merck.com/mmhe/sec06/ch076/ch076e.html


The central nervous system includes the brain and spinal cord. The brain and spinal cord are protected by bony structures, membranes, and fluid. The brain is held in the cranial cavity of the skull and it consists of the cerebrum, cerebellum, and the brain stem. The nerves involved are cranial nerves and spinal nerves.

Overview of the entire nervous system[edit]

The nervous system has three main functions: sensory input, integration of data and motor output. Sensory input is when the body gathers information or data, by way of neurons, glia and synapses. The nervous system is composed of excitable nerve cells (neurons) and synapses that form between the neurons and connect them to centers throughout the body or to other neurons. These neurons operate on excitation or inhibition, and although nerve cells can vary in size and location, their communication with one another determines their function. These nerves conduct impulses from sensory receptors to the brain and spinal cord. The data is then processed by way of integration of data, which occurs only in the brain. After the brain has processed the information, impulses are then conducted from the brain and spinal cord to muscles and glands, which is called motor output. Glia cells are found within tissues and are not excitable but help with myelination, ionic regulation and extracellular fluid.

The nervous system is comprised of two major parts, or subdivisions, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS includes the brain and spinal cord. The brain is the body's "control center". The CNS has various centers located within it that carry out the sensory, motor and integration of data. These centers can be subdivided to Lower Centers (including the spinal cord and brain stem) and Higher centers communicating with the brain via effectors. The PNS is a vast network of spinal and cranial nerves that are linked to the brain and the spinal cord. It contains sensory receptors which help in processing changes in the internal and external environment. This information is sent to the CNS via afferent sensory nerves. The PNS is then subdivided into the autonomic nervous system and the somatic nervous system. The autonomic has involuntary control of internal organs, blood vessels, smooth and cardiac muscles. The somatic has voluntary control of skin, bones, joints, and skeletal muscle. The two systems function together, by way of nerves from the PNS entering and becoming part of the CNS, and vice versa.

General functions of the CNS[edit]

When the central nervous system becomes damaged or peripheral nerves become trapped, it can increase or decrease your internal organs functionality, it can even affect your facial expressions, i.e. make you frown a lot, your smile becomes lop sided, your lungs can overwork, or underwork, the lung capacity is increased or decreased, your bladder can fill, but you are unable to urinate, your bowels become lapsed and you are unable to completely clear them upon each bowel movement, the muscles in your arms, legs and torso can become weaker and more fatty, not from lack of use, but from the nerves that run from your spine into them being restricted from working properly, you can suffer headaches, earaches, sore throats, blocked sinuses. Even your ability to orgasm can be affected.

CNS:
The "Central Nervous System", comprised of brain, brain stem, and spinal cord.


The central nervous system (CNS) represents the largest part of the nervous system, including the brain and the spinal cord. Together with the peripheral nervous system (PNS), it has a fundamental role in the control of behavior.

The CNS is conceived as a system devoted to information processing, where an appropriate motor output is computed as a response to a sensory input. Many threads of research suggest that motor activity exists well before the maturation of the sensory systems, and senses only influence behavior without dictating it. This has brought the conception of the CNS as an autonomous system.

Structure and function of neurons[edit]

Structure[edit]

Neurons are highly specialized for the processing and transmission of cellular signals. Given the diversity of functions performed by neurons in different parts of the nervous system, there is, as expected, a wide variety in the shape, size, and electrochemical properties of neurons. For instance, the soma of a neuron can vary in size from 4 to 100 micrometers in diameter.

The soma (cell body) is the central part of the neuron. It contains the nucleus of the cell, and therefore is where most protein synthesis occurs. The nucleus ranges from 3 to 18 micrometers in diameter. The dendrites of a neuron are cellular extensions with many branches, and metaphorically this overall shape and structure is referred to as a dendritic tree. This is where the majority of input to the neuron occurs. However, information outflow (i.e. from dendrites to other neurons) can also occur (except in chemical synapse in which backflow of impulse is inhibited by the fact that axon do not possess chemoreceptors and dendrites cannot secrete neurotransmitter chemical). This explains one way conduction of nerve impulse. The axon is a finer, cable-like projection which can extend tens, hundreds, or even tens of thousands of times the diameter of the soma in length. The axon carries nerve signals away from the soma (and also carry some types of information back to it). Many neurons have only one axon, but this axon may - and usually will - undergo extensive branching, enabling communication with many target cells. The part of the axon where it emerges from the soma is called the 'axon hillock'. Besides being an anatomical structure, the axon hillock is also the part of the neuron that has the greatest density of voltage-dependent sodium channels. This makes it the most easily-excited part of the neuron and the spike initiation zone for the axon: in neurological terms it has the greatest hyperpolarized action potential threshold. While the axon and axon hillock are generally involved in information outflow, this region can also receive input from other neurons as well. The axon terminal is a specialized structure at the end of the axon that is used to release neurotransmitter chemicals and communicate with target neurons. Although the canonical view of the neuron attributes dedicated functions to its various anatomical components, dendrites and axons often act in ways contrary to their so-called main function.

Axons and dendrites in the central nervous system are typically only about a micrometer thick, while some in the peripheral nervous system are much thicker. The soma is usually about 10–25 micrometers in diameter and often is not much larger than the cell nucleus it contains. The longest axon of a human motor neuron can be over a meter long, reaching from the base of the spine to the toes. Sensory neurons have axons that run from the toes to the dorsal columns, over 1.5 meters in adults. Giraffes have single axons several meters in length running along the entire length of their necks. Much of what is known about axonal function comes from studying the squids giant axon, an ideal experimental preparation because of its relatively immense size (0.5–1 millimeters thick, several centimeters long).

Function[edit]

Sensory afferent neurons convey information from tissues and organs into the central nervous system. Efferent neurons transmit signals from the central nervous system to the effector cells and are sometimes called motor neurons. Interneurons connect neurons within specific regions of the central nervous system. Afferent and efferent can also refer generally to neurons which, respectively, bring information to or send information from brain region.

Classification by action on other neurons

Excitatory neurons excite their target postsynaptic neurons or target cells causing it to function. Motor neurons and somatic neurons are all excitatory neurons. Excitatory neurons in the brain are often glutamatergic. Spinal motor neurons, which synapse on muscle cells, use acetylcholine as their neurotransmitter. Inhibitory neurons inhibit their target neurons. Inhibitory neurons are also known as short axon neurons, interneurons or microneurons. The output of some brain structures (neostriatum, globus pallidus, cerebellum) are inhibitory. The primary inhibitory neurotransmitters are GABA and glycine. Modulatory neurons evoke more complex effects termed neuromodulation. These neurons use such neurotransmitters as dopamine, acetylcholine, serotonin and others. Each synapses can receive both excitatory and inhibitory signals and the outcome is determined by the adding up of summation.

Excitatory and inhibitory process[edit]

The release of an excitatory neurotransmitter (e.g. glutamate) at the synapses will cause an inflow of positively charged sodium ions (Na+) making a localized depolarization of the membrane. The current then flows to the resting (polarized) segment of the axon.

Inhibitory synapse causes an inflow of Cl- (chlorine) or outflow of K+ (potassium) making the synaptic membrane hyperpolarized. This increase prevents depolarization, causing a decrease in the possibility of an axon discharge. If they are both equal to their charges, then the operation will cancel itself out. This effect is referred to as summation.

There are two types of summation: spatial and temporal. Spatial summation requires several excitatory synapses (firing several times) to add up, thus causing an axon discharge. It also occurs within inhibitory synapses, where just the opposite will occur. In temporal summation, it causes an increase of the frequency at the same synapses until it is large enough to cause a discharge. Spatial and temporal summation can occur at the same time as well.

The neurons of the brain release inhibitory neurotransmitters far more than excitatory neurotransmitters, which helps explain why we are not aware of all memories and all sensory stimuli simultaneously. The majority of information stored in the brain is inhibited most of the time.

Summation[edit]

When excitatory synapses exceed the amount of inhibitory synapses there are, then the excitatory synapses will prevail over the other. The same goes with inhibitory synapses, if there are more inhibitory synapses than excitatory, the synapses will be inhibited. To determine all of this is called summation.

Classification by discharge patterns:

Neurons can be classified according to their electrophysiological characteristics (note that a single action potential is not enough to move a large muscle, and instead will cause a twitch).

Tonic or regular spiking: Some neurons are typically constantly (or tonically) active. Example: interneurons in neurostriatum.

Phasic or bursting: Neurons that fire in bursts are called phasic.

Fast spiking: Some neurons are notable for their fast firing rates. For example, some types of cortical inhibitory interneurons, cells in globus pallidus.

Thin-spike: Action potentials of some neurons are more narrow compared to the others. For example, interneurons in prefrontal cortex are thin-spike neurons.

Classification by neurotransmitter released:

Some examples are cholinergic, GABAergic, glutamatergic and dopaminergic neurons.

Central Nervous System[edit]

The central nervous system is the control center for the body. It regulates organ function, higher thought, and movement of the body. The central nervous system consists of the brain and spinal cord.

Generation & propagation of an action potential[edit]

The Nerve Impulse[edit]

When a nerve is stimulated the resting potential changes. Examples of such stimuli are pressure, electricity, chemicals, etc. Different neurons are sensitive to different stimuli(although most can register pain). The stimulus causes sodium ion channels to open. The rapid change in polarity that moves along the nerve fiber is called the "action potential." In order for an action potential to occur, it must reach threshold. If threshold does not occur, then no action potential can occur. This moving change in polarity has several stages:

Depolarization
The upswing is caused when positively charged sodium ions (Na+) suddenly rush through open sodium gates into a nerve cell. The membrane potential of the stimulated cell undergoes a localized change from -55 millivolts to 0 in a limited area. As additional sodium rushes in, the membrane potential actually reverses its polarity so that the outside of the membrane is negative relative to the inside. During this change of polarity the membrane actually develops a positive value for a moment(+30 millivolts). The change in voltage stimulates the opening of additional sodium channels (called a voltage-gated ion channel). This is an example of a positive feedback loop.
Repolarization
The downswing is caused by the closing of sodium ion channels and the opening of potassium ion channels. Release of positively charged potassium ions (K+) from the nerve cell when potassium gates open. Again, these are opened in response to the positive voltage--they are voltage gated. This expulsion acts to restore the localized negative membrane potential of the cell (about -65 or -70 mV is typical for nerves).
Hyperpolarization

When the potassium ions are below resting potential (-90 mV). Since the cell is hyper polarized, it goes to a refractory phrase.

Refractory phase
The refractory period is a short period of time after the depolarization stage. Shortly after the sodium gates open, they close and go into an inactive conformation. The sodium gates cannot be opened again until the membrane is repolarized to its normal resting potential. The sodium-potassium pump returns sodium ions to the outside and potassium ions to the inside. During the refractory phase this particular area of the nerve cell membrane cannot be depolarized. This refractory area explains why action potentials can only move forward from the point of stimulation.

Factors that affect sensitivity and speed[edit]

Sensitivity
Increased permeability of the sodium channel occurs when there is a deficit of calcium ions. When there is a deficit of calcium ions (Ca+2) in the interstitial fluid, the sodium channels are activated (opened) by very little increase of the membrane potential above the normal resting level. The nerve fiber can therefore fire off action potentials spontaneously, resulting in tetany. This could be caused by the lack of hormone from parathyroid glands. It could also be caused by hyperventilation, which leads to a higher pH, which causes calcium to bind and become unavailable.
Speed of Conduction
This area of depolarization/repolarization/recovery moves along a nerve fiber like a very fast wave. In myelinated fibers, conduction is hundreds of times faster because the action potential only occurs at the nodes of Ranvier (pictured below in 'types of neurons') by jumping from node to node. This is called "saltatory" conduction. Damage to the myelin sheath by the disease can cause severe impairment of nerve cell function. Some poisons and drugs interfere with nerve impulses by blocking sodium channels in nerves. See discussion on drug at the end of this outline.

Brain[edit]

The brain is found in the cranial cavity. Within it are found the higher nerve centers responsible for coordinating the sensory and motor systems of the body (forebrain). The brain stem houses the lower nerve centers (consisting of midbrain, pons, and medulla),

Medulla[edit]

The medulla is the control center for respiratory, cardiovascular and digestive functions.

Pons[edit]

The pons houses the control centers for respiration and inhibitory functions. Here it will interact with the cerebellum.

Cerebrum[edit]

The cerebrum, or top portion of the brain, is divided by a deep crevice, called the longitudinal sulcus. The longitudinal sulcus separates the cerebrum in to the right and left hemispheres. In the hemispheres you will find the cerebral cortex, basal ganglia and the limbic system. The two hemispheres are connected by a bundle of nerve fibers called the corpus callosum. The right hemisphere is responsible for the left side of the body while the opposite is true of the left hemisphere. Each of the two hemispheres are divided into four separated lobes: the frontal in control of specialized motor control, learning, planning and speech; parietal in control of somatic sensory functions; occipital in control of vision; and temporal lobes which consists of hearing centers and some speech. Located deep to the temporal lobe of the cerebrum is the insula.

Cerebellum[edit]

The cerebellum is the part of the brain that is located posterior to the medulla oblongata and pons. It coordinates skeletal muscles to produce smooth, graceful motions. The cerebellum receives information from our eyes, ears, muscles, and joints about what position our body is currently in (proprioception). It also receives output from the cerebral cortex about where these parts should be. After processing this information, the cerebellum sends motor impulses from the brain stem to the skeletal muscles. The main function of the cerebellum is coordination. The cerebellum is also responsible for balance and posture. It also assists us when we are learning a new motor skill, such as playing a sport or musical instrument. Recent research shows that apart from motor functions cerebellum also has some emotional role.

The Limbic System and Higher Mental Functions[edit]


The Limbic System[edit]

The Limbic System is a complex set of structures found just beneath the cerebrum and on both sides of the thalamus. It combines higher mental functions, and primitive emotion, into one system. It is often referred to as the emotional nervous system. It is not only responsible for our emotional lives, but also our higher mental functions, such as learning and formation of memories. The Limbic system explains why some things seem so pleasurable to us, such as eating and why some medical conditions are caused by mental stress, such as high blood pressure. There are two significant structures within the limbic system and several smaller structures that are important as well. They are:

  1. The Hippocampus
  2. The Amygdala
  3. The Thalamus
  4. The Hypothalamus
  5. The Fornix and Parahippocampus
  6. The Cingulate Gyrus

Structures of the Limbic System[edit]

Hippocampus[edit]
The Hippocampus is found deep in the temporal lobe, shaped like a seahorse. It consists of two horns that curve back from the amygdala. It is situated in the brain so as to make the prefrontal area aware of our past experiences stored in that area. The prefrontal area of the brain consults this structure to use memories to modify our behavior. The hippocampus is a primary contributor to memory.
Amygdala[edit]
The Amygdala is a little almond shaped structure, deep inside the anteroinferior region of the temporal lobe, that connects with the hippocampus, the septi nuclei, the prefrontal area and the medial dorsal nucleus of the thalamus. These connections make it possible for the amygdala to play its important role on the mediation and control of such activities and feelings as love, friendship, affection, and expression of mood. The amygdala is the center for identification of danger and is fundamental for self preservation. The amygdala is the nucleus responsible for fear.
Thalamus[edit]
Lesions or stimulation of the medial, dorsal, and anterior nuclei of the thalamus are associated with changes in emotional reactivity. However, the importance of these nuclei on the regulation of emotional behavior is not due to the thalamus itself, but to the connections of these nuclei with other limbic system structures. The medial dorsal nucleus makes connections with cortical zones of the prefrontal area and with the hypothalamus. The anterior nuclei connect with the mamillary bodies and through them, via fornix, with the hippocampus and the cingulated gyrus, thus taking part in what is known as the Papez's circuit.
Hypothalamus[edit]
The Hypothalamus is a small part of the brain located just below the thalamus on both sides of the third ventricle. Lesions of the hypothalamus interfere with several vegetative functions and some so called motivated behaviors like sexuality, combativeness, and hunger. The hypothalamus also plays a role in emotion. Specifically, the lateral parts seem to be involved with pleasure and rage, while the medial part is linked to aversion, displeasure, and a tendency to uncontrollable and loud laughing. However, in general the hypothalamus has more to do with the expression of emotions. When the physical symptoms of emotion appear, the threat they pose returns, via the hypothalamus, to the limbic centers and then the prefrontal nuclei, increasing anxiety.
The Fornix and Parahippocampal[edit]
These small structures are important connecting pathways for the limbic system.
The Cingulate Gyrus[edit]
The Cingulate Gyrus is located in the medial side of the brain between the cingulated sulcus and the corpus callosum. There is still much to be learned about this gyrus, but it is already known that its frontal part coordinates smells and sights, with pleasant memories of previous emotions. The region participates in the emotional reaction to pain and in the regulation of aggressive behavior.

Memory and Learning[edit]

Memory is defined as : The mental faculty of retaining and recalling past experiences, the act or instance of remembering recollection. Learning takes place when we retain and utilize past memories.

Overall, the mechanisms of memory are not completely understood. Brain areas such as the hippocampus, the amygdala, the striatum, or the mammillary bodies are thought to be involved in specific types of memory. For example, the hippocampus is believed to be involved in spatial learning and declarative learning (learning information such as what you're reading now), while the amygdala is thought to be involved in emotional memory. Damage to certain areas in patients and animal models and subsequent memory deficits is a primary source of information. However, rather than implicating a specific area, it could be that damage to adjacent areas, or to a pathway traveling through the area is actually responsible for the observed deficit. Further, it is not sufficient to describe memory, and its counterpart, learning, as solely dependent on specific brain regions. Learning and memory are attributed to changes in neuronal synapses, thought to be mediated by long-term potentiation and long-term depression.

There are three basic types of memory:

  1. Sensory Memory
  2. Short Term Memory
  3. Long Term Memory
Sensory Memory[edit]
The sensory memories act as a buffer for stimuli through senses. A sensory memory retains an exact copy of what is seen or heard: iconic memory for visual, echoic memory for aural and haptic memory for touch. Information is passed from sensory memory into short term memory. Some believe it lasts only 300 milliseconds, it has unlimited capacity. Selective attention determines what information moves from sensory memory to short term memory.
Short Term Memory[edit]
Short Term Memory acts as a scratch pad for temporary recall of the information under process. For instance, in order to understand this sentence you need to hold in your mind the beginning of the sentence as you read the rest. Short term memory decays rapidly and also has a limited capacity. Chunking of information can lead to an increase in the short term memory capacity, this is the reason why a hyphenated phone number is easier to remember than a single long number. The successful formation of a chunk is known as closure. Interference often causes disturbance in short term memory retention. This accounts for the desire to complete a task held in short term memory as soon as possible.

Within short term memory there are three basic operations:

  1. Iconic memory - the ability to hold visual images
  2. Acoustic memory - the ability to hold sounds. Can be held longer than iconic.
  3. Working memory - an active attentional process to keep it until it is put to use. Note that the goal is not really to move the information from short term memory to long term memory, but merely to put it to immediate use.

The process of transferring information from short term to long term memory involves the encoding or consolidation of information. This is not a function of time, that is, the longer the memory stays in the short term the more likely it is to be placed in the long term memory. On organizing complex information in short term before it can be encoded into the long term memory, in this process the meaningfulness or emotional content of an item may play a greater role in its retention in the long term memory. The limbic system sets up local reverberating circuits such as the Papez's Circuit.

Long Term Memory[edit]
Long Term Memory is used for storage of information over a long time. Information from short to long term memory is transferred after a short period. Unlike short term memory, long term memory has little decay. Long term potential is an enhanced response at the synapse within the hippocampus. It is essential to memory storage. The limbic system isn't directly involved in long term memory necessarily but it selects them from short term memory, consolidates these memories by playing them like a continuous tape, and involves the hippocampus and amygdala.

There are two types of long term memory:

  1. Episodic Memory
  2. Semantic Memory

Episodic memory represents our memory of events and experiences in a serial form. It is from this memory that we can reconstruct the actual events that took place at a given point in our lives. Semantic memory, on the other hand, is a structured record of facts, concepts, and skills that we have acquired. The information in the semantic memory is derived from our own episode memory, such as that we can learn new facts or concepts from experiences.

There are three main activities that are related to long term memory:

  1. Storage
  2. Deletion
  3. Retrieval

Information for short term memory is stored in long term memory by rehearsal. The repeated exposure to a stimulus or the rehearsal of a piece of information transfers it into long term memory. Experiments also suggest that learning is most effective if it is distributed over time. Deletion is mainly caused by decay and interference. Emotional factors also affect long term memory. However, it is debatable whether we actually ever forget anything or whether it just sometimes becomes increasingly difficult to retrieve it. Information may not be recalled sometimes but may be recognized, or may be recalled only with prompting. This leads us to the third operation of memory, information retrieval.

There are two types of information retrieval:

  1. Recall
  2. Recognition

In recall, the information is reproduced from memory. In recognition the presentation of the information provides the knowledge that the information has been seen before. Recognition is of lesser complexity, as the information is provided as a cue. However, the recall may be assisted by the provision of retrieval cues which enable the subject to quickly access the information in memory.

Long-term Potentiation[edit]

.

Long-term potentiation (LTP) is the lasting enhancement of connections between two neurons that results from stimulating them simultaneously. Since neurons communicate via chemical synapses, and because memories are believed to be stored by virtue of patterns of activation of these synapses, LTP and its opposing process, long-term depression, are widely considered the major cellular mechanisms that underlie learning and memory. This has been proven by lab experiments. When one of the chemicals involved (PKMzeta, it will be discussed later) is inhibited in rats, it causes retrograde amnesia with short term memory left intact (meaning they can't recall events from before the inhibitor was given).

By enhancing synaptic transmission, LTP improves the ability of two neurons, one presynaptic and the other postsynaptic, to communicate with one another across a synapse. The precise mechanism for this enhancement isn't known, but it varies based on things like brain region, age and species. This will focus on LTP in the CA1 section of the hippocampus, because that's what is well known.

The end result of LTP is a well established neural circuit that can be called upon later for memory.

LTP in the CA1 hippocampus is called NMDA receptor-dependent LTP. It has four main properties.

LTP can be rapidly induced by applying one or more brief, high-frequency, stimulus to a presynaptic cell.
Once induced, LTP at one synapse does not spread to other synapses; rather LTP is input specific. LTP is only propagated to those synapses according to the rules of associativity and cooperativity.
Associativity refers to the observation that when weak stimulation of a single pathway is insufficient for the induction of LTP, simultaneous strong stimulation of another pathway will induce LTP at both pathways.
LTP can be induced either by strong tetanic stimulation of a single pathway to a synapse, or cooperatively via the weaker stimulation of many. When one pathway into a synapse is stimulated weakly, it produces insufficient postsynaptic depolarization to induce LTP. In contrast, when weak stimuli are applied to many pathways that converge on a single patch of postsynaptic membrane, the individual postsynaptic depolarizations generated may collectively depolarize the postsynaptic cell enough to induce LTP cooperatively. Synaptic tagging, discussed later, may be a common mechanism underlying associativity and cooperativity.

LTP is generally divided into three parts that occur sequentially: Short-term potentiation, early LTP (E-LTP) and late LTP (L-LTP). Short-term potentiation isn't well understood and will not be discussed.

E-LTP and L-LTP phases of LTP are each characterized by a series of three events: induction, maintenance and expression. Induction happens when a short-lived signal triggers that phase to begin. Maintenance corresponds to the persistent biochemical changes that occur in response to the induction of that phase. Expression entails the long-lasting cellular changes that result from activation of the maintenance signal.

Each phase of LTP has a set of mediator molecules that dictate the events of that phase. These molecules include protein receptors, enzymes, and signaling molecules that allow progression from one phase to the next. In addition to mediators, there are modulator molecules that interact with mediators to fine tune the LTP. Modulators are a bit beyond the scope of this introductory book, and won't be discussed here.

Early Phase[edit]
Induction

E-LTP induction begins when the calcium inside the postsynaptic cell exceeds a threshold. In many types of LTP, the flow of calcium into the cell requires the NMDA receptor, which is why these types of LTP are considered NMDA receptor-dependent.

When a stimulus is applied to the presynaptic neuron, it releases a neurotransmitter, typically glutamate, onto the postsynaptic cell membrane where it binds to AMPA receptors, or AMPARs. This causes an influx of sodium ions into the postsynaptic cell, this short lived depolarization is called the excitatory postsynaptic potential (EPSP) and makes it easier for the neuron to fire an action potential.

A single stimulus doesn't cause a big enough depolarization to trigger an E-LTP, instead it relies on EPSP summation. If EPSPs are reaching the cell before the others decay, they will add up. When the depolarization reaches a critical level, NMDA receptors lose the magnesium molecule they were originally plugged with and let calcium in. The rapid rise in calcium within the postsynaptic neuron trigger the short lasting activation of several enzymes that mediate E-LTP induction. Of particular importance are some protein kinase enzymes, including CaMKII and PKC. To a lesser extent, PKA and MAPK activation also contribute.

Maintenance

During the maintenance stage of E-LTP, CaMKII and PKC lose their dependence on calcium and become autonomously active. They then carry out phosphorylation that underlies E-LTP expression.

Expression

CaMKII and PKC phosphorylate existing AMPA receptors to increase their activity, and mediate the insertion of additional AMPA receptors onto the postsynaptic cell membrane. This is achieved by having a pool of nonsynaptic AMPA receptors adjacent to the postsynaptic membrane. When the appropriate stimulus arrives, the nonsynaptic AMPA receptors are brought into the postsynaptic membrane under the influence of protein kinases.

AMPA receptors are one of the most common type of receptors in the brain. Their effect is excitatory. By adding more AMPA receptors, and increasing their activity, future stimuli will generate larger postsynaptic responses.

Late Phase[edit]

Late LTP is the natural extension of E-LTP. L-LTP requires gene transcription and protein synthesis in the postsynaptic cell, unlike E-LTP. Late LTP is also associated with the presynaptic synthesis of synaptotagmin and an increase in synaptic vesicle number, suggesting that L-LTP induces protein synthesis not only in postsynaptic cells, but in presynaptic cells as well. This is discussed under "retrograde messenger" below.

Induction

Late LTP is induced by changes in gene expression and protein synthesis brought about by persistent activation of protein kinases activated during E-LTP, such as MAPK. In fact, MAPK--Specifically the ERK subfamily of MAPKs--may be the molecular link between E-LTP and L-LTP, since many signaling cascades involved in E-LTP, including CaMKII and PKC, can converge on ERK.

Maintenance

Upon activation, ERK may phosphorylate a number of cytoplasmic and nuclear molecules that ultimately result in the protein synthesis and morphological changes associated with L-LTP. These chemicals may include transcription factors such as CREB. ERK-mediated changes in transcription factor activity may trigger the synthesis of proteins that underlie the maintenance of L-LTP. PKMzeta is one such molecule. When this molecule is inhibited in rats, they experience retrograde amnesia (where you can't recall previous events but short term memory works fine).

Expression

Aside from PKMzeta, many of the proteins synthesized during L-LTP are unknown. They are though to increase postsynaptic dendritic spine number, surface area and sensitivity to the neurotransmitter associated with L-LTP expression.

Retrograde Signaling[edit]

Retrograde signaling is a hypothesis that attempts to explain that, while LTP is induced and expressed postsynaptically, some evidence suggests that it is expressed presynaptically as well. The hypothesis gets its name because normal synaptic transmission is directional and proceeds from the presynaptic to the postsynaptic cell. For induction to occur postsynaptically and be partially expressed presynaptically, a message must travel from the postsynaptic cell to the presynaptic cell in a retrograde (reverse) direction. Once there, the message presumably initiates a cascade of events that leads to a presynaptic component of expression, such as the increased probability of neurotransmitter vesicle release.

Retrograde signaling is currently a contentious subject as some investigators do not believe the presynaptic cell contributes at all to the expression of LTP. Even among proponents of the hypothesis there is controversy over the identity of the messenger.

Language and Speech[edit]

Language depends on semantic memory so some of the same areas in the brain are involved in both memory and language. Articulation, the forming of speech, is represented bilaterally in the motor areas. However, for most individuals, language analysis and speech formation take place in regions of the left hemisphere only. The two major cortical regions involved are:

  1. Broca's Area
  2. Wernicke's Area

Broca's area is located just in front of the voice control area of the left motor cortex. This region assembles the motor sequencing of language, speech and writing. For example, patients with lesions in this area:

  1. Are unable to understand language perfectly: they are typically able to understand nouns better than verbs or syntactical words and fragments
  2. May not be able to write clearly
  3. Usually speak in fragmented phrases and sentences, often with effort

Wernicke's area is part of the auditory and visual associations cortex. This region is responsible for the analysis and formation of language content. For example, patients with lesions in this area:

  1. Have difficulty naming objects
  2. Have difficulty understand the meaning of words
  3. Articulate speech readily but often with distorted or unintelligible meaning

Diseases of the Limbic System[edit]

There are several well known diseases that are disorders of the limbic system. Several are discussed here.

Schizophrenia[edit]

An increased dopamine (DA) response in the limbic system results in schizophrenia. DA may be synthesized or secreted in excess, DA receptors may be supersensitive, and DA regulatory mechanism may be defective. Symptoms are decreased by drugs which block DA receptors. Symptoms of schizophrenia are:

  1. Loss of touch with reality
  2. Decreased ability to think and reason
  3. Decreased ability to concentrate
  4. Decreased memory
  5. Regress in child-like behavior
  6. Altered mood and impulsive behavior
  7. Auditory hallucinations

Symptoms may be so severe that the individual cannot function.

Depression[edit]

Depression is the most common major mental illness and is characterized by both emotional and physical symptoms. Symptoms of depression are:

  1. Intense sadness and despair
  2. Anxiety
  3. Loss of ability to concentrate
  4. Pessimism
  5. Feelings of low self esteem
  6. Insomnia or hypersomnia
  7. Increased or decreased appetite
  8. Changes in body temperature and endocrine gland function

10 to 15% of depressed individuals display suicidal behavior during their lifetime.

The cause of depression and its symptoms are a mystery but we do understand that it is an illness associated with biochemical changes in the brain. A lot of research goes on to explain that it is associated with a lack of amines serotonin and norephinephrine. Therefore pharmacological treatment strategies often try to increase amine concentrations in the brain.

One class of antidepressants is monoamine oxidase inhibitors. Mono amine oxidase is an enzyme that breaks down your amines like norephinephrine and serotonin. Because the antidepressants inhibit their degradation they will remain in the synaptic cleft for a longer period of time making the effect just as if you had increased these types of neurotransmitters.

A newer class of antidepressants is selective serotonin reuptake inhibitors (SSRI's). With SSRI's decreasing the uptake of serotonin back into the cell that will increase the amount of serotonin present in the synaptic cleft. SSRI's are more specific than the monoamine oxidase inhibitors because they only affect serotonergic synapses. You might recognize these SSRI's by name as Prozac and Paxil.

Bipolar Disorder[edit]

Another common form of depression is manic depression. Mania is an acute state characterized by:

  1. Excessive elation and impaired judgment
  2. Insomnia and irritability
  3. Hyperactivity
  4. Uncontrolled speech

Manic depression, also known as bipolar disorder, displays mood swings between mania and depression. The limbic system receptors are unregulated. Drugs used are unique mood stabilizers.

The hippocampus is particularly vulnerable to several disease processes, including ischemia, which is any obstruction of blood flow or oxygen deprivation, Alzheimer’s disease, and epilepsy. These diseases selectively attack CA1, which effectively cuts through the hippocampal circuit.

An Autism Link[edit]

A connection between autism and the limbic system has also been noted as well. URL: http://www.autism.org/limbic.html

Case Study[edit]

Central Pain Syndrome

I was 42 years old when my life changed forever. I had a stroke. As an avid viewer of medical programs on television I assumed that I would have physical therapy for my paralyzed left side and get on with my life. No one ever mentioned pain or the possibility of pain, as a result of the stroke. I did experience unusual sensitivity to touch while still in the hospital, but nothing to prepare me for what was to come.

The part of my brain that is damaged is the Thalamus. This turns out to be the pain center and what I have now is an out of control Thalamus, resulting in Thalamic Pain syndrome, also called Central Pain Syndrome. This means that 24 hours a day, seven days a week, my brain sends messages of pain and it never goes away. I am under the care of physicians, who not only understand chronic pain, but are also willing to treat it with whatever medications offer some help. None of the medications, not even narcotic medications, take the pain away. They just allow me to manage it so I can function.

The Peripheral Nervous System[edit]

The peripheral nervous system includes 12 cranial nerves 31 pairs of spinal nerves. It can be subdivided into the somatic and autonomic systems. It is a way of communication from the central nervous system to the rest of the body by nerve impulses that regulate the functions of the human body.

The twelve cranial nerves are

I Olfactory Nerve for smell
II Optic Nerve for vision
III Oculomotor for looking around
IV Trochlear for moving eye
V Trigeminal for feeling touch on face
VI Abducens to move eye muscles
VII Facial to smile, wink, and help us taste
VIII Vestibulocochlear to help with balance, equilibrium, and hearing
IX Glossopharyngeal for swallowing and gagging
X Vagus for swallowing, talking, and parasympathetic actions of digestion
XI Spinal accessory for shrugging shoulders
XII Hypoglossal for tongue more divided into different regions as muscles

10 out of the 12 cranial nerves originate from the brain stem (I and II are in the cerebrum), and mainly control the functions of the anatomic structures of the head with some exceptions. CN X receives visceral sensory information from the thorax and abdomen, and CN XI is responsible for innervating the sternocleidomastoid and trapezius muscles, neither of which is exclusively in the head.

Spinal nerves take their origins from the spinal cord. They control the functions of the rest of the body. In humans, there are 31 pairs of spinal nerves: 8 cervical, 12 thoracic, 5 lumbar, 5 sacral and 1 coccygeal. The naming convention for spinal nerves is to name it after the vertebra immediately above it. Thus the fourth thoracic nerve originates just below the fourth thoracic vertebra. This convention breaks down in the cervical spine. The first spinal nerve originates above the first cervical vertebra and is called C1. This continues down to the last cervical spinal nerve, C8. There are only 7 cervical vertebrae and 8 cervical spinal nerves.

Lateral cord[edit]

The lateral cord gives rise to the following nerves:

  • The lateral pectoral nerve, C5, C6 and C7 to the pectoralis major muscle, or musculus pectoralis major.
  • The musculocutaneous nerve which innervates the biceps muscle
  • The median nerve, partly. The other part comes from the medial cord. See below for details.

Posterior cord[edit]

The posterior cord gives rise to the following nerves:

  • The upper subscapular nerve, C7 and C8, to the subscapularis muscle, or musculus supca of the rotator cuff.
  • The lower subscapular nerve, C5 and C6, to the teres major muscle, or the musculus teres major, also of the rotator cuff.
  • The thoracodorsal nerve, C6, C7 and C8, to the latissimus dorsi muscle, or musculus latissimus dorsi.
  • The axillary nerve, which supplies sensation to the shoulder and motor to the deltoid muscle or musculus deltoideus, and the teres minor muscle, or musculus teres minor.
  • The radial nerve, or nervus radialis, which innervates the triceps brachii muscle, the brachioradialis muscle, or musculus brachioradialis,, the extensor muscles of the fingers and wrist (extensor carpi radialis muscle), and the extensor and abductor muscles of the thumb. See radial nerve injuries.

Medial cord[edit]

The medial cord gives rise to the following nerves:

  • The median pectoral nerve, C8 and T1, to the pectoralis muscle
  • The medial brachial cutaneous nerve, T1
  • The medial antebrachial cutaneous nerve, C8 and T1
  • The median nerve, partly. The other part comes from the lateral cord. C7, C8 and T1 nerve roots. The first branch of the median nerve is to the pronator teres muscle, then the flexor carpi radialis, the palmaris longus and the flexor digitorum superficialis. The median nerve provides sensation to the anterior palm, the anterior thumb, index finger and middle finger. It is the nerve compressed in carpal tunnel syndrome.
  • The ulnar nerve originates in nerve roots C7, C8 and T1. It provides sensation to the ring and pinky fingers. It innervates the flexor carpi ulnaris muscle, the flexor digitorum profundus muscle to the ring and pinky fingers, and the intrinsic muscles of the hand (the interosseous muscle, the lumbrical muscles and the flexor pollicus brevis muscle). This nerve traverses a groove on the elbow called the cubital tunnel, also known as the funny bone. Striking the nerve at this point produces an unpleasant sensation in the ring and little fingers.

Other thoracic spinal nerves (T3-T12)[edit]

The remainder of the thoracic spinal nerves, T3 through T12, do little recombining. They form the intercostal nerves, so named because they run between the ribs. For points of reference, the 7th intercostal nerve terminates at the lower end of the sternum, also known as the xyphoid process. The 10th intercostal nerve terminates at the umbilicus, or the belly button.

The somatic nervous system is that part of the peripheral nervous system associated with the voluntary control of body movements through the action of skeletal muscles, and also reception of external stimuli. The somatic nervous system consists of afferent fibers that receive information from external sources, and efferent fibers that are responsible for muscle contraction. The somatic system includes the pathways from the skin and skeletal muscles to the Central Nervous System. It is also described as involved with activities that involve consciousness.

The basic route of the efferent somatic nervous system includes a two neuron sequence. The first is the upper motor neuron, whose cell body is located in the precentral gyrus (Brodman Area 4) of the brain. It receives stimuli from this area to control skeletal (voluntary) muscle. The upper motor neuron carries this stimulus down the corticospinal tract and synapses in the ventral horn of the spinal cord with the alpha motor neuron, a lower motor neuron. The upper motor neuron releases acetylcholine from its axon terminal knobs and these are received by nicotinic receptors on the alpha motor neuron. The alpha motor neurons cell body sends the stimulus down its axon via the ventral root of the spinal cord and proceeds to its neuromuscular junction of its skeletal muscle. There, it releases acetylcholine from its axon terminal knobs to the muscles nicotinic receptors, resulting in stimulus to contract the muscle.

The somatic system includes all the neurons connected with the muscles, sense organs and skin. It deals with sensory information and controls the movement of the body.

The Autonomic System[edit]

The Autonomic system deals with the visceral organs, like the heart, stomach, gland, and the intestines. It regulates systems that are unconsciously carried out to keep our body alive and well, such as breathing, digestion (peristalsis), and regulation of the heartbeat. The Autonomic system consists of the sympathetic and the parasympathetic divisions. Both divisions work without conscious effort, and they have similar nerve pathways, but the sympathetic and parasympathetic systems generally have opposite effects on target tissues (they are antagonistic). By controlling the relative input from each division, the autonomic system regulates many aspects of homeostasis. One of the main nerves for the parasympathetic autonomic system is Cranial Nerve X, the Vagus nerve.

The Sympathetic and Parasympathetic Systems[edit]

The sympathetic nervous system activates what is often termed the fight or flight response, as it is most active under sudden stressful circumstances (such as being attacked). This response is also known as sympathetico-adrenal response of the body, as the pre-ganglionic sympathetic fibers that end in the adrenal medulla (but also all other sympathetic fibers) secrete acetylcholine, which activates the secretion of adrenaline (epinephrine) and to a lesser extent noradrenaline (norepinephrine) from it. Therefore, this response that acts primarily on the cardiovascular system is mediated directly via impulses transmitted through the sympathetic nervous system and indirectly via catecholamines secreted from the adrenal medulla.

Western science typically looks at the SNS as an automatic regulation system, that is, one that operates without the intervention of conscious thought. Some evolutionary theorists suggest that the sympathetic nervous system operated in early organisms to maintain survival (Origins of Consciousness, Robert Ornstein; et al.), as the sympathetic nervous system is responsible for priming the body for action. One example of this priming is in the moments before waking, in which sympathetic outflow spontaneously increases in preparation for action.

The parasympathetic nervous system is part of the autonomic nervous system. Sometimes called the rest and digest system or feed and breed. The parasympathetic system conserves energy as it slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gastrointestinal tract.

After high stress situations (ie: fighting for your life) the parasympathetic nervous system has a backlash reaction that balances out the reaction of the sympathetic nervous system. For example, the increase in heart rate that comes along with a sympathetic reaction will result in an abnormally slow heart rate during a parasympathetic reaction.

Organization[edit]

Sympathetic nerves originate inside the vertebral column, toward the middle of the spinal cord in the intermediolateral cell column (or lateral horn), beginning at the first thoracic segment of the spinal cord and extending into the second or third lumbar segments. Because its cells begin in the thoracic and lumbar regions of the spinal cord, the SNS is said to have a thoracolumbar outflow. Axons of these nerves leave the spinal cord in the ventral branches (rami) of the spinal nerves, and then separate out as 'white rami' (so called from the shiny white sheaths of myelin around each axon) which connect to two chain ganglia extending alongside the vertebral column on the left and right. These elongated ganglia are also known as paravertebral ganglia or sympathetic trunks. In these hubs, connections (synapses) are made which then distribute the nerves to major organs, glands, and other parts of the body. [1]

In order to reach the target organs and glands, the axons must travel long distances in the body, and, to accomplish this, many axons link up with the axon of a second cell. The ends of the axons do not make direct contact, but rather link across a space, the synapse.

In the SNS and other components of the peripheral nervous system, these synapses are made at sites called ganglia. The cell that sends its fiber is called a preganglionic cell, while the cell whose fiber leaves the ganglion is called a postganglionic cell. As mentioned previously, the preganglionic cells of the SNS are located between the first thoracic segment and the second or third lumbar segments of the spinal cord. Postganglionic cells have their cell bodies in the ganglia and send their axons to target organs or glands.

The ganglia include not just the sympathetic trunks but also the superior cervical ganglion (which sends sympathetic nerve fibers to the head), and the celiac and mesenteric ganglia (which send sympathetic fibers to the gut).

Information transmission[edit]

Messages travel through the SNS in a bidirectional flow. Efferent messages can trigger changes in different parts of the body simultaneously. For example, the sympathetic nervous system can accelerate heart rate; widen bronchial passages; decrease motility (movement) of the large intestine; constrict blood vessels; increase peristalsis in the esophagus; cause pupil dilation, piloerection (goose bumps) and perspiration (sweating); and raise blood pressure. Afferent messages carry sensations such as heat, cold, or pain.

The first synapse (in the sympathetic chain) is mediated by nicotinic receptors physiologically activated by acetylcholine, and the target synapse is mediated by adrenergic receptors physiologically activated by either noradrenaline or adrenaline. An exception is with sweat glands which receive sympathetic innervation but have muscarinic acetylcholine receptors which are normally characteristic of PNS. Another exception is with certain deep muscle blood vessels, which have acetylcholine receptors and which dilate (rather than constrict) with an increase in sympathetic tone. The sympathetic system cell bodies are located on the spinal cord excluding the cranial and sacral regions, specifically the thoracolumbar region (T1-L3). The preganglonic neurons exit from the vertebral column and synapse with the postganglonic neurons in the sympathetic trunk.

The parasympathetic nervous system is one of three divisions of the autonomic nervous system. Sometimes called the rest and digest system, the parasympathetic system conserves energy as it slows the heart rate, increases intestinal and gland activity, and relaxes sphincter muscles in the gastrointestinal tract.

Relationship to sympathetic[edit]

While an oversimplification, it is said that the parasympathetic system acts in a reciprocal manner to the effects of the sympathetic nervous system; in fact, in some tissues innervated by both systems, the effects are synergistic.

Receptors[edit]

The parasympathetic nervous system uses only acetylcholine (ACh) as its neurotransmitter. The ACh acts on two types of receptors, the muscarinic and nicotinic cholinergic receptors. Most transmissions occur in two stages: When stimulated, the preganglionic nerve releases ACh at the ganglion, which acts on nicotinic receptors of the postganglionic nerve. The postganglionic nerve then releases ACh to stimulate the muscarinic receptors of the target organ.


The three main types of muscarinic receptors that are well characterised are:

  • The M1 muscarinic receptors are located in the neural system.
  • The M2 muscarinic receptors are located in the heart, and act to bring the heart back to normal after the actions of the sympathetic nervous system: slowing down the heart rate, reducing contractile forces of the atrial cardiac muscle, and reducing conduction velocity of the atrioventricular node (AV node). Note, they have no effect on the contractile forces of the ventricular muscle.
  • The M3 muscarinic receptors are located at many places in the body, such as the smooth muscles of the blood vessels, as well as the lungs, which means that they cause vasoconstriction and bronchoconstriction. They are also in the smooth muscles of the gastrointestinal tract (GIT), which help in increasing intestinal motility and dilating sphincters. The M3 receptors are also located in many glands that help to stimulate secretion in salivary glands and other glands of the body.

Nervous Tissue[edit]

The nervous system coordinates the activity of the muscles, monitors the organs, constructs and also stops input from the senses, and initiates actions. Prominent participants in a nervous system include neurons and nerves, which play roles in such coordination.Our nervous tissue only consists of two types of cells. These cells are neurons and neuroglia cells. The neurons are responsible for transmitting nerve impulses. Neuroglia cells are responsible for supporting and nourishing the neuron cells.

Types of Neurons[edit]

There are three types of neurons in the body. We have sensory neurons, interneurons, and motor neurons. Neurons are a major class of cells in the nervous system. Neurons are sometimes called nerve cells, though this term is technically imprecise, as many neurons do not form nerves. In vertebrates, neurons are found in the brain, the spinal cord and in the nerves and ganglia of the peripheral nervous system. Their main role is to process and transmit information. Neurons have excitable membranes, which allow them to generate and propagate electrical impulses. Sensory neuron takes nerve impulses or messages right from the sensory receptor and delivers it to the central nervous system. A sensory receptor is a structure that can find any kind of change in it's surroundings or environment.

Structure of a neuron[edit

Brain, brain stem, and spinal cord.

Electrical characteristics of a neurochemical action potential.
animated action potential

A color-coded image of the brain, showing the main sections.

Image of the brain, showing the Limbic system.

Image of the brain showing the location of the hypothalamus.

diagram showing human dermatoms, i.e., skin regions with respect to the routing of their nerve connection of their afferent nerves through the spinal cord.

Figure 1: The right sympathetic chain and its connections with the thoracic, abdominal, and pelvic plexuses. (After Schwalbe.)

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